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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
9.09
Human Site:
S150
Identified Species:
15.38
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S150
H
D
E
G
D
Q
C
S
R
L
L
E
L
V
K
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S150
H
D
E
G
D
Q
C
S
R
L
L
E
L
V
K
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S150
H
D
E
G
D
Q
C
S
R
L
L
E
L
V
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
H152
L
V
K
D
I
S
S
H
L
D
V
T
A
L
C
Rat
Rattus norvegicus
O54735
833
94538
E150
Y
S
L
F
L
V
C
E
D
S
S
K
D
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
L152
V
K
D
I
S
S
H
L
D
V
T
A
L
C
H
Chicken
Gallus gallus
P52731
862
99990
A143
F
P
L
D
I
G
I
A
G
W
V
A
H
T
K
Frog
Xenopus laevis
NP_001088271
859
97399
L144
V
K
D
I
S
S
H
L
D
V
T
A
L
C
H
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
L148
V
R
D
V
S
S
H
L
D
L
T
A
L
C
H
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
E161
L
K
E
H
N
E
R
E
F
F
L
E
L
V
K
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
E405
L
K
Q
L
D
E
K
E
L
I
F
E
L
V
K
Honey Bee
Apis mellifera
XP_394107
1016
115998
D185
L
N
R
L
D
E
S
D
L
F
M
E
L
I
R
Nematode Worm
Caenorhab. elegans
P91119
710
81117
L79
S
D
N
R
T
R
I
L
Y
E
I
T
Q
C
C
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
A157
D
R
C
S
L
F
L
A
R
G
T
K
D
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
0
6.6
N.A.
6.6
6.6
6.6
13.3
40
33.3
20
6.6
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
20
20
N.A.
20
20
20
20
53.3
53.3
53.3
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
15
0
0
0
29
8
0
0
% A
% Cys:
0
0
8
0
0
0
29
0
0
0
0
0
0
29
15
% C
% Asp:
8
29
22
15
36
0
0
8
29
8
0
0
15
0
0
% D
% Glu:
0
0
29
0
0
22
0
22
0
8
0
43
0
0
0
% E
% Phe:
8
0
0
8
0
8
0
0
8
15
8
0
0
0
8
% F
% Gly:
0
0
0
22
0
8
0
0
8
8
0
0
0
0
0
% G
% His:
22
0
0
8
0
0
22
8
0
0
0
0
8
0
22
% H
% Ile:
0
0
0
15
15
0
15
0
0
8
8
0
0
8
0
% I
% Lys:
0
29
8
0
0
0
8
0
0
0
0
15
0
8
43
% K
% Leu:
29
0
15
15
15
0
8
29
22
29
29
0
65
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
22
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
15
8
8
0
8
8
0
29
0
0
0
0
8
15
% R
% Ser:
8
8
0
8
22
29
15
22
0
8
8
0
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
0
29
15
0
8
0
% T
% Val:
22
8
0
8
0
8
0
0
0
15
15
0
0
36
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _